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                           May 17, 2022

       Andrew Robbins
       President and Chief Executive Officer
       Cogent Biosciences, Inc.
       200 Cambridge Park Drive, Suite 2500
       Cambridge, Massachusetts 02140

                                                        Re: Cogent Biosciences,
Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed May 6, 2022
                                                            File No. 333-264773

       Dear Mr. Robbins:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Dillon
Hagius at 202-551-7967 with any questions.




                           Sincerely,


                           Division of Corporation Finance

                           Office of Life Sciences
       cc:                                              Ryan A. Murr